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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5l7dCLRSmoothened homolog

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5l7dCLRSmoothened homolog/1.000
4l9q9TPSerum albumin/0.466
3slkNDPPolyketide synthase extender module 2/0.460
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.454
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.454
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.451
1iyzNDPProbable quinone oxidoreductase/0.450
4y8wSTRSteroid 21-hydroxylase/0.447
1yb5NAPQuinone oxidoreductase1.6.5.50.446
1cc2FADCholesterol oxidase1.1.3.60.444
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2q61SF1Peroxisome proliferator-activated receptor gamma/0.442
4fehFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.442
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.441
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
1osvCHCBile acid receptor/0.440
2j3iNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.440
3dl9V2HVitamin D 25-hydroxylase/0.440
3h0aD30Peroxisome proliferator-activated receptor gamma/0.440
3p6nDSOCamphor 5-monooxygenase1.14.15.10.440