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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5jinSAMHistone-lysine N-methyltransferase EHMT2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5jinSAMHistone-lysine N-methyltransferase EHMT2/1.000
2o8jSAHHistone-lysine N-methyltransferase EHMT2/0.657
5jj0SAMHistone-lysine N-methyltransferase EHMT2/0.603
3mo0SAHHistone-lysine N-methyltransferase EHMT1/0.598
3hnaSAHHistone-lysine N-methyltransferase EHMT1/0.593
5jhnSAMHistone-lysine N-methyltransferase EHMT2/0.574
2igqSAHHistone-lysine N-methyltransferase EHMT1/0.570
3fpdSAHHistone-lysine N-methyltransferase EHMT1/0.556
3kmtSAHHistone H3K27 methylase/0.547
2rfiSAHHistone-lysine N-methyltransferase EHMT1/0.544
3swcSAHHistone-lysine N-methyltransferase EHMT1/0.532
5czySAMEukaryotic huntingtin interacting protein B/0.510
3ru0SFGHistone-lysine N-methyltransferase SMYD32.1.1.430.489
3cbpSFGHistone-lysine N-methyltransferase SETD72.1.1.430.468
3ooiSAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific2.1.1.430.467
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.463
2cekN8TAcetylcholinesterase3.1.1.70.462
4qenSAHHistone-lysine N-methyltransferase, H3 lysine-9 specific SUVH42.1.1.430.462
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.460
2h21SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.456
3pdnSFGHistone-lysine N-methyltransferase SMYD32.1.1.430.454
2g226IGRenin3.4.23.150.451
4j4nD44Peptidylprolyl isomerase/0.450
4ynmSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.450
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.449
3n71SFGHistone-lysine N-methyltransferase Smyd1/0.446
4j83SAMHistone-lysine N-methyltransferase SETD72.1.1.430.444
4o30SAHProbable Histone-lysine N-methyltransferase ATXR52.1.1.430.444
1bil0IURenin3.4.23.150.442
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.442
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.442
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.442
4ypeSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.442