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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5fx2FMNFlavodoxin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5fx2FMNFlavodoxin/1.000
1fx1FMNFlavodoxin/0.594
1akrFMNFlavodoxin/0.564
1akwFMNFlavodoxin/0.563
4fx2FMNFlavodoxin/0.555
1c7fFMNFlavodoxin/0.546
1azlFMNFlavodoxin/0.539
1j9gFMNFlavodoxin/0.537
2fx2FMNFlavodoxin/0.534
1bu5RBFFlavodoxin/0.530
1wsbFMNFlavodoxin/0.530
1j8qFMNFlavodoxin/0.527
3f6sFMNFlavodoxin/0.527
5tgzFMNCannabinoid receptor 1/0.526
3f6rFMNFlavodoxin/0.523
3ojxFMNNADPH--cytochrome P450 reductase/0.510
1akuFMNFlavodoxin/0.508
3f90FMNFlavodoxin/0.503
4y7cFMNNADPH--cytochrome P450 reductase/0.499
1ja0FMNNADPH--cytochrome P450 reductase/0.498
5xraFMNCannabinoid receptor 1/0.496
1xyvFMNFlavodoxin/0.482
4nv0MG77-methylguanosine phosphate-specific 5'-nucleotidase/0.477
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.475
1j9zFMNNADPH--cytochrome P450 reductase/0.475
3hr4FMNNitric oxide synthase, inducible1.14.13.390.471
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.469
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.468
2bf4FMNNADPH--cytochrome P450 reductase/0.465
2xlrFADPutative flavin-containing monooxygenase/0.463
4b78KGGBeta-secretase 13.4.23.460.463
5a4vQUEGlutathione S-transferase F22.5.1.180.463
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.462
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.461
2z1qFADAcyl-CoA dehydrogenase/0.460
2bn4FMNNADPH--cytochrome P450 reductase/0.458
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.456
2xysSY9Soluble acetylcholine receptor/0.455
4r81FMNPredicted NADH dehydrogenase/0.455
1ja1FMNNADPH--cytochrome P450 reductase/0.454
3ojwFMNNADPH--cytochrome P450 reductase/0.454
3qfrFMNNADPH--cytochrome P450 reductase/0.454
3fktSIIBeta-secretase 13.4.23.460.453
4twnB96Ephrin type-A receptor 32.7.10.10.453
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.453
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.452
3ig6438Urokinase-type plasminogen activator3.4.21.730.452
1jqdSAHHistamine N-methyltransferase2.1.1.80.451
2fcrFMNFlavodoxin/0.451
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.450
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.448
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.448
2vn1FK5Peptidylprolyl isomerase/0.447
4e32DWNMethyltransferase/0.447
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.445
3s7dLEU_SER_LYS_LYS_MLZN-lysine methyltransferase SMYD2/0.445
4ohwATPProtein clpf-1/0.445
3kaqFMNFlavodoxin/0.444
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.444
1rkwPNTHTH-type transcriptional regulator QacR/0.443
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3m4p4ADAsparaginyl-tRNA synthetase, putative/0.441
3q9bB3NAcetylpolyamine amidohydrolase/0.441
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.441
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.440
3qe2FMNNADPH--cytochrome P450 reductase/0.440
4i0h1BLBeta-secretase 13.4.23.460.440