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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5cb3APRO-acetyl-ADP-ribose deacetylase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5cb3APRO-acetyl-ADP-ribose deacetylase/1.000
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.561
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.560
5cb5APRO-acetyl-ADP-ribose deacetylase/0.552
5fsxADPUncharacterized protein/0.521
4b1iA8PPoly(ADP-ribose) glycohydrolase3.2.1.1430.512
4b1hAR6Poly(ADP-ribose) glycohydrolase3.2.1.1430.488
4na4A1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.488
4b1jA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.487
3siiA1RUncharacterized protein/0.481
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.473
3v2bAR6Poly [ADP-ribose] polymerase 152.4.2.300.472
3sigAR6Uncharacterized protein/0.469
2nq8ZIDEnoyl-ACP reductase/0.462
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.462
3uelA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.462
3zc3NAPFerredoxin--NADP reductase1.18.1.20.461
4r81FMNPredicted NADH dehydrogenase/0.459
3gqoAPRNon-structural polyprotein/0.458
3w8dNAD3-hydroxybutyrate dehydrogenase/0.458
4d86ADPPoly [ADP-ribose] polymerase 142.4.2.300.451
3vtdTKDVitamin D3 receptor/0.450
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1psa0ZLPepsin A3.4.23.10.449
1qorNDPQuinone oxidoreductase 1/0.449
1ty8ADPProbable ADP-ribose 1''-phosphate phosphatase YML087W3.1.3.840.449
1v35NAIEnoyl-ACP reductase/0.448
5fsyAR6Uncharacterized protein/0.448
3p9tTCLRepressor/0.447
2hcdBIVVitamin D3 receptor A/0.446
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.445
2uxoTACHTH-type transcriptional regulator TtgR/0.445
3vrwYS5Vitamin D3 receptor/0.441
1opbRETRetinol-binding protein 2/0.440
4q71FADBifunctional protein PutA/0.440