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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5c7hNDPPutative oxidoreductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5c7hNDPPutative oxidoreductase/1.000
4pmjNAPPutative oxidoreductase/0.705
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.506
2hdjNDPAldo-keto reductase family 1 member C2/0.500
3h7rNAPAldo-keto reductase family 4 member C8/0.497
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.488
1adsNAPAldose reductase1.1.1.210.486
4l1xNAPAldo-keto reductase family 1 member C2/0.483
1ah4NAPAldose reductase1.1.1.210.482
2pf8NDPAldose reductase1.1.1.210.476
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.476
4jq3NAPAldo-keto reductase family 1 member C2/0.473
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.470
1z9aNADNAD(P)H-dependent D-xylose reductase1.1.1.3070.470
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.469
4xo7NAPAldo-keto reductase family 1 member C2/0.469
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.468
3q65NAPAldose reductase1.1.1.210.468
4jtqNAPAldo-keto reductase family 1 member C2/0.467
2hejNDPAldo-keto reductase family 1 member C211.1.10.466
2j8tNAPAldose reductase1.1.1.210.466
1zgdNAPChalcone reductase/0.465
2pevNDPAldose reductase1.1.1.210.465
2pfhNDPAldose reductase1.1.1.210.465
4g5dNDPProstaglandin F synthase1.1.1.1880.465
1c9wNAPAldose reductase-related protein 2/0.464
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.464
1x98NAPAldose reductase1.1.1.210.464
1vp5NAPOxidoreductase, aldo/keto reductase family/0.462
1z8aNAPAldose reductase1.1.1.210.461
2acqNAPAldose reductase1.1.1.210.460
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.460
2vdgNDPAldose reductase1.1.1.210.458
1x96NAPAldose reductase1.1.1.210.457
4dz5NAPAldo-keto reductase family 1 member C3/0.457
1az2NAPAldose reductase1.1.1.210.455
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.452
3q67NAPAldose reductase1.1.1.210.452
4xzmNAPAldo-keto reductase family 1 member B101.1.10.452
1ye4NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.451
2iq0NAPAldose reductase1.1.1.210.451
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.451
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.448
3v36NAPAldose reductase1.1.1.210.446