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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5b2zGNPGTPase HRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5b2zGNPGTPase HRas/1.000
3l8yGNPGTPase HRas/0.768
3i3sGNPGTPase HRas/0.688
3rs5GNPGTPase HRas/0.645
3v4fGNPGTPase HRas/0.642
3lbnGNPGTPase HRas/0.638
3oivGNPGTPase HRas/0.615
3oiuGNPGTPase HRas/0.612
4nyiGNPGTPase HRas/0.610
3ddcGNPGTPase HRas/0.608
3kucGDPRas-related protein Rap-1A/0.600
3rs7GNPGTPase HRas/0.600
5dhaGNPGTP-binding nuclear protein Ran/0.600
3kkoGNPRas-related protein M-Ras/0.599
4k81GTPGTPase HRas/0.598
3x1zGNPRas-related protein Rap-1b/0.593
3rabGNPRas-related protein Rab-3A/0.592
3w3zGTPGTP-binding nuclear protein Ran/0.590
3oiwGNPGTPase HRas/0.588
4dltGNPGTPase HRas/0.588
4lhwGNPRas-related protein Rab-8A/0.587
3tsoGNPRas-related protein Rab-25/0.584
4dlwGNPGTPase HRas/0.584
3rslGNPGTPase HRas/0.581
2rgbGNPGTPase HRas/0.579
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.578
4qxaGTPRas-related protein Rab-9A/0.578
4rkfGNPRas-related protein Rab-3/0.577
2rgcGNPGTPase HRas/0.571
4nyjGNPGTPase HRas/0.571
2c5lGTPGTPase HRas/0.570
3a6pGTPGTP-binding nuclear protein Ran/0.569
3ea5GDPGTP-binding nuclear protein Ran/0.569
1e96GTPRas-related C3 botulinum toxin substrate 1/0.568
1yzqGNPRas-related protein Rab-6A/0.567
2gilGTPRas-related protein Rab-6A/0.567
1zd9GDPADP-ribosylation factor-like protein 8A/0.566
2zetGTPRas-related protein Rab-27B/0.566
3rs4GNPGTPase HRas/0.566
4hdoGNPRas-related protein Rap-1b/0.566
3e5hGNPRas-related protein Rab-28/0.564
3pitGNPRas-related protein M-Ras/0.563
4dlxGNPGTPase HRas/0.563
4dsnGCPGTPase KRas/0.562
4dlzGNPGTPase HRas/0.560
1g17GNPRas-related protein SEC4/0.559
1xtsGTPGTP-binding protein Rheb/0.559
4mitGTPRho-related protein racC/0.559
1ibrGNPGTP-binding nuclear protein Ran/0.558
1zbdGTPRas-related protein Rab-3A/0.558
3kudGDPGTPase HRas/0.558
3lbiGNPGTPase HRas/0.558
4g0nGNPGTPase HRas/0.557
1zc3GNPRas-related protein Ral-A/0.556
2rgeGNPGTPase HRas/0.556
1t91GTPRas-related protein Rab-7a/0.555
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.554
3k8yGNPGTPase HRas/0.551
3bbpGTPRas-related protein Rab-6A/0.548
3rs0GNPGTPase HRas/0.547
3lbhGNPGTPase HRas/0.546
3nbzGTPGTP-binding nuclear protein Ran/0.546
4kvgGTPRas-related protein Rap-1A/0.544
1zc4GNPRas-related protein Ral-A/0.543
4dsuGDPGTPase KRas/0.541
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.538
3a58GNPGTP-binding protein RHO1/0.538
3oesGNPGTPase RhebL1/0.537
4o25GTPGTP-binding protein Rheb/0.537
5difGNPGTP-binding nuclear protein Ran/0.536
3tnfGNPRas-related protein Rab-8A/0.534
4ol0GTPGTP-binding nuclear protein Ran/0.534
1xtrGNPGTP-binding protein Rheb/0.533
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.531
3lawGNPRas-related protein Rab-7a/0.531
3qbtGNPRas-related protein Rab-8A/0.530
1oixGDPRas-related protein Rab-11A/0.527
3bc1GNPRas-related protein Rab-27A/0.526
5jljGNPGTP-binding nuclear protein Ran/0.526
4dlsGNPGTPase HRas/0.525
4l9wGNPGTPase HRas/0.525
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.521
4dlvGNPGTPase HRas/0.521
4l9sGDPGTPase HRas/0.521
3wyfGTPGTP-binding nuclear protein/0.519
4obeGDPGTPase KRas/0.515
1kmqGNPTransforming protein RhoA/0.514
4tq9GDPGTPase KRas/0.510
2ce2GDPGTPase HRas/0.509
1yhnGTPRas-related protein Rab-7a/0.508
4hdqGNPRas-related protein Rap-1b/0.507
1lfdGNPGTPase HRas/0.506
2rggGNPGTPase HRas/0.506
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.505
2ffqGSPRas-related protein Rab-6B/0.504
4cymGCPRas-related protein Rab-32/0.503
4dsoGSPGTPase KRas/0.503
1m7bGTPRho-related GTP-binding protein RhoE/0.502
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.502
1vg8GNPRas-related protein Rab-7a/0.502
4o2lGTPGTP-binding protein Rheb/0.502
1s1cGNPTransforming protein RhoA/0.501
2clsGTPRho-related GTP-binding protein Rho6/0.501
2fe4GDPRas-related protein Rab-6B/0.501
2bkuGTPGTP-binding nuclear protein Ran/0.498
3tklGTPRas-related protein Rab-1A/0.497
3mjhGTPRas-related protein Rab-5A/0.494
3eg5GNPCell division control protein 42 homolog/0.493
1cxzGSPTransforming protein RhoA/0.492
1uadGNPRas-related protein Ral-A/0.492
4uj3GNPRas-related protein Rab-11A/0.491
4q03GDPGTPase KRas/0.490
4wa7GDPGTPase KRas/0.490
1a2bGSPTransforming protein RhoA/0.488
4lucGDPGTPase KRas/0.488
1k5dGNPGTP-binding nuclear protein Ran/0.487
3kz1GSPTransforming protein RhoA/0.487
4dxaGSPRas-related protein Rap-1b/0.485
2msdGNPMHC class I alpha chain/0.484
1yu9GNPRas-related protein Rab-4A/0.483
4js0GNPCell division control protein 42 homolog/0.483
4lpkGDPGTPase KRas/0.482
4xoiGTPTransforming protein RhoA/0.482
4xvrGNPGTPase HRas/0.482
1n6lGTPRas-related protein Rab-5A/0.480
2cl6CAGGTPase HRas/0.480
3tgpGNPGTPase HRas/0.478
4q02GDPGTPase KRas/0.478
4ql3GDPGTPase KRas/0.478
2gcpGSPRho-related GTP-binding protein RhoC/0.477
4epxGDPGTPase KRas/0.477
5c46GSPRas-related protein Rab-11A/0.477
1g16GDPRas-related protein SEC4/0.476
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.475
5hpyGDPTransforming protein RhoA/0.475
3cphGDPRas-related protein SEC4/0.471
4epwGDPGTPase KRas/0.471
4o2rGDPGTP-binding protein Rheb/0.467
1z2aGDPRas-related protein Rab-23/0.466
3th5GNPRas-related C3 botulinum toxin substrate 1/0.466
3kkqGDPRas-related protein M-Ras/0.465
1ow3GDPTransforming protein RhoA/0.464
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.464
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.463
4l8gGDPGTPase KRas/0.463
4xvqGNPGTPase HRas/0.463
1d5cGDPGTPase (Rab6)/0.462
4uj5GNPRas-related protein Rab-11A/0.461
2ic5GNPRas-related C3 botulinum toxin substrate 3/0.460
3k9lGNPGTPase HRas/0.457
4lv6GDPGTPase KRas/0.456
1x1rGDPRas-related protein M-Ras/0.454
1tu3GNPRas-related protein Rab-5A/0.453
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.453
2fg5GNPRas-related protein Rab-31/0.449
4lrwGDPGTPase KRas/0.448
4ldjGDPGTPase KRas/0.446
2j5xGSPADP-ribosylation factor 6/0.445
3v2uATPProtein GAL3/0.442
4oi2ADPProtein clpf-1/0.442
2bmeGNPRas-related protein Rab-4A/0.441