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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4zseANPEpidermal growth factor receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4zseANPEpidermal growth factor receptor2.7.10.11.000
5cnnANPEpidermal growth factor receptor2.7.10.10.557
5cnoANPEpidermal growth factor receptor2.7.10.10.545
4j95ACPFibroblast growth factor receptor 2/0.478
4k33ACPFibroblast growth factor receptor 32.7.10.10.477
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.472
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.467
4i22IREEpidermal growth factor receptor2.7.10.10.467
2xa4AZ5Tyrosine-protein kinase JAK2/0.464
3c50ADPRhodopsin kinase/0.462
1u54ACPActivated CDC42 kinase 1/0.457
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.455
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
5eg3ACPFibroblast growth factor receptor 2/0.450
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4mb2ATPUncharacterized protein/0.448
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.447
1p9wANPType II secretion system protein E/0.443
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.441
3nynSGVG protein-coupled receptor kinase 62.7.11.160.441
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.440
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.440