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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4zqcF6FTryptophan synthase alpha chain

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4zqcF6FTryptophan synthase alpha chain/1.000
4wx2F6FTryptophan synthase alpha chain/0.619
4wx2F6FTryptophan synthase beta chain4.2.1.200.619
4y6gF6FTryptophan synthase alpha chain/0.619
2clfF6FTryptophan synthase alpha chain/0.568
1k7fIAVTryptophan synthase alpha chain/0.567
2cleF6FTryptophan synthase alpha chain/0.554
1k8zIAGTryptophan synthase alpha chain/0.526
2clmF6FTryptophan synthase alpha chain/0.522
1kfbIGPTryptophan synthase alpha chain/0.506
2rh9IGPTryptophan synthase alpha chain/0.505
3k1wBFXRenin3.4.23.150.490
1a5bIGPTryptophan synthase alpha chain/0.487
3oadLPORenin3.4.23.150.487
1qoqIGPTryptophan synthase alpha chain/0.479
1kfcIPLTryptophan synthase alpha chain/0.478
1g63FMNEpidermin decarboxylase4.1.10.470
3g6zA7TRenin3.4.23.150.468
3g70A5TRenin3.4.23.150.465
3slkNDPPolyketide synthase extender module 2/0.463
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
3g72A6TRenin3.4.23.150.461
3oagLPQRenin3.4.23.150.457
3wqmB29Diterpene synthase3.1.7.80.455
2bktRPFRenin3.4.23.150.453
4c49HCYCorticosteroid-binding globulin/0.452
1beuIPLTryptophan synthase alpha chain/0.449
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
4b00I6XBeta-secretase 13.4.23.460.449
1tllFMNNitric oxide synthase, brain1.14.13.390.446
2g263LGRenin3.4.23.150.446
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.446
4xoqF42Coenzyme F420:L-glutamate ligase/0.446
3pm1ETHTH-type transcriptional regulator QacR/0.445
4klaCHDFerrochelatase, mitochondrial4.99.1.10.445
2jfgUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.444
3q43D66M1 family aminopeptidase3.4.110.444
3vjcZGASqualene synthase2.5.1.210.444
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.444
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.443
4b6uM7GEukaryotic translation initiation factor 4E type 3/0.443
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.442
4h3j10WBeta-secretase 13.4.23.460.441
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.441
2dvlFADAcyl-CoA dehydrogenase/0.440
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.440