scPDB - Distribution of Binding site Similarity values of 4x5j entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4x5j	FOL	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	1.000
4x5i	FOL	Dihydrofolate reductase	1.5.1.3	0.575
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.560
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.557
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.553
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.549
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.547
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.544
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.535
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.531
2d0k	FOL	Dihydrofolate reductase	1.5.1.3	0.530
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.527
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.526
4x5h	FOL	Dihydrofolate reductase	1.5.1.3	0.526
1ra3	MTX	Dihydrofolate reductase	1.5.1.3	0.525
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.524
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.523
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.518
1rd7	FOL	Dihydrofolate reductase	1.5.1.3	0.511
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.510
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.509
5hi6	MTX	Dihydrofolate reductase	/	0.508
1rb2	FOL	Dihydrofolate reductase	1.5.1.3	0.504
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.502
1ra8	FOL	Dihydrofolate reductase	1.5.1.3	0.501
1rf7	DHF	Dihydrofolate reductase	1.5.1.3	0.500
1dyi	FOL	Dihydrofolate reductase	1.5.1.3	0.494
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.492
4qi9	MTX	Dihydrofolate reductase	/	0.486
1jom	FFO	Dihydrofolate reductase	1.5.1.3	0.478
4elb	34S	Dihydrofolate reductase	/	0.474
1rx7	FOL	Dihydrofolate reductase	1.5.1.3	0.472
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.471
1dyh	DZF	Dihydrofolate reductase	1.5.1.3	0.466
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.448
1dhi	MTX	Dihydrofolate reductase	1.5.1.3	0.444
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.441
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.440
4ele	31I	Dihydrofolate reductase	/	0.440