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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4wf0FMNNPH1-1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4wf0FMNNPH1-1/1.000
2cn8DBQSerine/threonine-protein kinase Chk22.7.11.10.477
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.459
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.457
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.455
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3ormAGSSerine/threonine protein kinase/0.450
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.448
4o0uADNAurora kinase A2.7.11.10.447
4yqfGDPSeptin-9/0.447
1pf9ADP60 kDa chaperonin/0.446
4bebATPType I restriction enzyme EcoR124II R protein3.1.21.30.446
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.445
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.445
2q0uLABActin, alpha skeletal muscle/0.444
4mb2ATPUncharacterized protein/0.444
1merDMQGag-Pol polyprotein3.4.23.160.443
3h0sB38Acetyl-CoA carboxylase/0.443
4e5h0N8Polymerase acidic protein/0.443
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.442
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3zokNAD3-dehydroquinate synthase, chloroplastic4.2.3.40.440