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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ug2NGIAdenosine receptor A2a

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ug2NGIAdenosine receptor A2a/1.000
4uhrNGIAdenosine receptor A2a/0.559
5k2aZMAAdenosine receptor A2a/0.550
5k2cZMAAdenosine receptor A2a/0.541
5uviZMAAdenosine receptor A2a/0.539
5k2bZMAAdenosine receptor A2a/0.537
5iua6DXAdenosine receptor A2a/0.536
5iubCLRAdenosine receptor A2a/0.535
5k2dZMAAdenosine receptor A2a/0.531
5iu86DZAdenosine receptor A2a/0.519
5jtbZMAAdenosine receptor A2a/0.518
3emlZMAAdenosine receptor A2a/0.500
5iu4ZMAAdenosine receptor A2a/0.498
2ydvNECAdenosine receptor A2a/0.494
4eiyZMAAdenosine receptor A2a/0.491
2ydoADNAdenosine receptor A2a/0.486
5g53NECAdenosine receptor A2a/0.475
4o8aFADBifunctional protein PutA1.2.1.880.467
3qakUKAAdenosine receptor A2a/0.457
4iaq2GM5-hydroxytryptamine receptor 1B/0.456
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
4j6cSTRCytochrome P450 monooxygenase/0.442
1tj0FADBifunctional protein PutA1.5.5.20.441
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3o3nIRC(R)-2-hydroxyisocaproyl-CoA dehydratase alpha subunit/0.440