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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ube2FAAdenosine kinase2.7.1.20

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4ube2FAAdenosine kinase2.7.1.201.000
2pkk2FAAdenosine kinase2.7.1.200.935
2pkmADNAdenosine kinase2.7.1.200.656
3fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.467
3fapARDSerine/threonine-protein kinase mTOR2.7.11.10.467
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.460
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.460
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.459
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.459
4mqt2CUMuscarinic acetylcholine receptor M2/0.458
4h3i10VBeta-secretase 13.4.23.460.457
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.453
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.453
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.453
4azy7F3Beta-secretase 13.4.23.460.451
4h3f10OBeta-secretase 13.4.23.460.451
1e1qANPATP synthase subunit alpha, mitochondrial/0.450
1e1qANPATP synthase subunit beta, mitochondrial3.6.3.140.450
2hldANPATP synthase subunit alpha, mitochondrial/0.450
2hldANPATP synthase subunit beta, mitochondrial3.6.3.140.450
2c27MA8Mycothiol acetyltransferase2.3.1.1890.447
3zksWZVBeta-secretase 23.4.23.450.447
2p5uNADUDP-glucose 4-epimerase/0.445
3b1pNOSPfkB carbohydrate kinase family protein/0.444
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.443
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.443
1z71L17Prothrombin3.4.21.50.443
3oeeANPATP synthase subunit alpha, mitochondrial/0.442
3oeeANPATP synthase subunit beta, mitochondrial3.6.3.140.442
2ejzSAHDiphthine synthase/0.441