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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.91.000
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.723
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.632
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.586
4u0k744Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.575
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.568
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.563
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.555
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.530
3fnfJPMEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.496
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.491
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.489
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.487
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.482
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.478
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.472
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.467
5hs1VORLanosterol 14-alpha demethylase/0.467
2dvlFADAcyl-CoA dehydrogenase/0.461
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.455
4bqrIBHEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
4bj9UHBTankyrase-22.4.2.300.449
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.447
1fmjRTLRetinol dehydratase/0.446
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.446
3fne8PCEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.442
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440