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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4s33ANPMitogen-activated protein kinase 12.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4s33ANPMitogen-activated protein kinase 12.7.11.241.000
4s34ANPMitogen-activated protein kinase 12.7.11.240.502
4gt3ATPMitogen-activated protein kinase 12.7.11.240.497
1qmzATPCyclin-dependent kinase 22.7.11.220.487
4qnyANPMitogen activated protein kinase, putative/0.477
4eooATPCyclin-dependent kinase 22.7.11.220.475
2ojj82AMitogen-activated protein kinase 12.7.11.240.472
5dosATPAurora kinase A2.7.11.10.466
4s32ANPMitogen-activated protein kinase 12.7.11.240.464
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.462
4ii5ADPCyclin-dependent kinase 22.7.11.220.455
4fv6E57Mitogen-activated protein kinase 12.7.11.240.451
4h3qANPMitogen-activated protein kinase 12.7.11.240.451
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.450
4xlvACPInsulin receptor2.7.10.10.446
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.445
3i60E86Mitogen-activated protein kinase 12.7.11.240.445
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.445
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.443
5dnrATPAurora kinase A2.7.11.10.443
3gu7ADPDeath-associated protein kinase 12.7.11.10.441