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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4r1fADPDNA topoisomerase 2-alpha5.99.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4r1fADPDNA topoisomerase 2-alpha5.99.1.31.000
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.639
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.615
1pvgANPDNA topoisomerase 25.99.1.30.568
1z5cADPType 2 DNA topoisomerase 6 subunit B/0.497
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.487
1nhhANPDNA mismatch repair protein MutL/0.478
3h4lANPDNA mismatch repair protein PMS1/0.465
2e0aANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.461
1i59ANPChemotaxis protein CheA2.7.13.30.459
1z5aADPType 2 DNA topoisomerase 6 subunit B/0.458
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.457
1mx0ANPType 2 DNA topoisomerase 6 subunit B/0.451
1thnADPAnti-sigma F factor/0.442
4h3f10OBeta-secretase 13.4.23.460.441