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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4qosADPPsp operon transcriptional activator

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4qosADPPsp operon transcriptional activator/1.000
2c96ATPPsp operon transcriptional activator/0.539
2c9cATPPsp operon transcriptional activator/0.501
1drbMTXDihydrofolate reductase1.5.1.30.469
3r9uFADThioredoxin reductase/0.464
1xddAAYIntegrin alpha-L/0.463
3wfjNAD2-dehydropantoate 2-reductase/0.446
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.445
2bunFADAppA protein/0.444
4j0r1H2Bromodomain-containing protein 4/0.444
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.442
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441