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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4qecNAPElxO

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4qecNAPElxO/1.000
4qedNAPElxO/0.610
1xkqNDPUncharacterized protein/0.505
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.482
1xg5NAPDehydrogenase/reductase SDR family member 11/0.478
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.476
1ipeNDPTropinone reductase 21.1.1.2360.474
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
3gy0NAPNAD(P)-dependent oxidoreductase/0.460
3l77NJPShort-chain alcohol dehydrogenase/0.460
1w4zNAPPutative ketoacyl reductase1.3.10.459
1ae1NAPTropinone reductase 1/0.458
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.457
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.456
4esoNAPPutative oxidoreductase/0.456
1snyNAPLD36273p/0.454
2jahNDPClavaldehyde dehydrogenase/0.454
1n5dNDPCarbonyl reductase [NADPH] 1/0.452
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.452
3toxNAPPutative oxidoreductase/0.452
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.450
1x7gNAPPutative ketoacyl reductase1.3.10.447
3lqfNADGalactitol dehydrogenase/0.447
3ai3NDPNADPH-sorbose reductase/0.446
4dc1NDPPutative ketoacyl reductase1.3.10.443
4hwkNAPSepiapterin reductase1.1.1.1530.443
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.442
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.442
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.441
3ai2NDPNADPH-sorbose reductase/0.441
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.441
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3sjuNDPKeto reductase/0.440
4j7uNAPSepiapterin reductase1.1.1.1530.440