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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4pooSAMPutative RNA methylase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4pooSAMPutative RNA methylase/1.000
3eeySAMrRNA methylase/0.550
3lbySAHUncharacterized protein/0.545
3gqvNAPEnoyl reductase LovC10.471
3b70NAPEnoyl reductase LovC10.465
3qvxNADMyo-inositol-1-phosphate synthase (Ino1)/0.464
2v16C47Renin3.4.23.150.462
4qi7FADCellobiose dehydrogenase/0.460
3b6zCO7Enoyl reductase LovC10.459
2v13C40Renin3.4.23.150.457
3kec3KECollagenase 33.4.240.454
2vnaNAPProstaglandin reductase 21.3.1.480.451
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.450
5dbgNADIridoid synthase1.3.1.990.450
2ou2ACOHistone acetyltransferase KAT5/0.449
2ym2NAPPhenylacetone monooxygenase1.14.13.920.446
3mddFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.445
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.443
1jqiFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.441
3vyeVYERenin3.4.23.150.441
2y0mACOHistone acetyltransferase KAT8/0.440