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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4o2lGTPGTP-binding protein Rheb

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4o2lGTPGTP-binding protein Rheb/1.000
1xtsGTPGTP-binding protein Rheb/0.582
1xtrGNPGTP-binding protein Rheb/0.577
3kkoGNPRas-related protein M-Ras/0.558
3pitGNPRas-related protein M-Ras/0.555
3oesGNPGTPase RhebL1/0.551
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.547
3lbhGNPGTPase HRas/0.545
3ddcGNPGTPase HRas/0.544
3lbnGNPGTPase HRas/0.543
3a6pGTPGTP-binding nuclear protein Ran/0.542
4o2rGDPGTP-binding protein Rheb/0.542
1ibrGNPGTP-binding nuclear protein Ran/0.540
4g0nGNPGTPase HRas/0.540
3bbpGTPRas-related protein Rab-6A/0.538
3lawGNPRas-related protein Rab-7a/0.537
3w3zGTPGTP-binding nuclear protein Ran/0.532
1d5cGDPGTPase (Rab6)/0.529
1t91GTPRas-related protein Rab-7a/0.529
3kz1GSPTransforming protein RhoA/0.529
5difGNPGTP-binding nuclear protein Ran/0.529
4dsnGCPGTPase KRas/0.528
3e5hGNPRas-related protein Rab-28/0.527
5dhaGNPGTP-binding nuclear protein Ran/0.527
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.524
4ol0GTPGTP-binding nuclear protein Ran/0.522
1yhnGTPRas-related protein Rab-7a/0.521
3k8yGNPGTPase HRas/0.521
5jljGNPGTP-binding nuclear protein Ran/0.521
4hdoGNPRas-related protein Rap-1b/0.520
2rgcGNPGTPase HRas/0.517
4mitGTPRho-related protein racC/0.517
1zbdGTPRas-related protein Rab-3A/0.516
2rgeGNPGTPase HRas/0.516
5b2zGNPGTPase HRas/0.516
1yzqGNPRas-related protein Rab-6A/0.515
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.515
3eg5GNPCell division control protein 42 homolog/0.515
3oivGNPGTPase HRas/0.514
4nyiGNPGTPase HRas/0.514
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.513
2fe4GDPRas-related protein Rab-6B/0.512
3v4fGNPGTPase HRas/0.511
3rs0GNPGTPase HRas/0.510
2zetGTPRas-related protein Rab-27B/0.509
4dltGNPGTPase HRas/0.509
1kmqGNPTransforming protein RhoA/0.508
2gcpGSPRho-related GTP-binding protein RhoC/0.508
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.508
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.508
3tnfGNPRas-related protein Rab-8A/0.508
3kucGDPRas-related protein Rap-1A/0.506
3nbzGTPGTP-binding nuclear protein Ran/0.506
4nyjGNPGTPase HRas/0.506
1cxzGSPTransforming protein RhoA/0.505
1e96GTPRas-related C3 botulinum toxin substrate 1/0.504
2c5lGTPGTPase HRas/0.503
2ffqGSPRas-related protein Rab-6B/0.503
3wyfGTPGTP-binding nuclear protein/0.502
3lbiGNPGTPase HRas/0.501
1z2aGDPRas-related protein Rab-23/0.500
2rgbGNPGTPase HRas/0.499
3mjhGTPRas-related protein Rab-5A/0.499
4qxaGTPRas-related protein Rab-9A/0.499
4rkfGNPRas-related protein Rab-3/0.499
2bkuGTPGTP-binding nuclear protein Ran/0.498
3ea5GDPGTP-binding nuclear protein Ran/0.498
3l8yGNPGTPase HRas/0.496
3rs4GNPGTPase HRas/0.496
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.495
3x1zGNPRas-related protein Rap-1b/0.493
3oiuGNPGTPase HRas/0.492
3rslGNPGTPase HRas/0.492
4o25GTPGTP-binding protein Rheb/0.492
1zd9GDPADP-ribosylation factor-like protein 8A/0.489
4tq9GDPGTPase KRas/0.488
1vg8GNPRas-related protein Rab-7a/0.487
4k81GTPGTPase HRas/0.487
3oiwGNPGTPase HRas/0.486
4lucGDPGTPase KRas/0.486
3rabGNPRas-related protein Rab-3A/0.485
3qbtGNPRas-related protein Rab-8A/0.484
4dlsGNPGTPase HRas/0.484
3rs5GNPGTPase HRas/0.482
3rs7GNPGTPase HRas/0.482
4js0GNPCell division control protein 42 homolog/0.482
1k5dGNPGTP-binding nuclear protein Ran/0.481
1zc4GNPRas-related protein Ral-A/0.481
4dlwGNPGTPase HRas/0.481
4l8gGDPGTPase KRas/0.481
1g17GNPRas-related protein SEC4/0.479
2msdGNPMHC class I alpha chain/0.478
3i3sGNPGTPase HRas/0.478
3a58GNPGTP-binding protein RHO1/0.475
2gilGTPRas-related protein Rab-6A/0.473
1s1cGNPTransforming protein RhoA/0.472
2rggGNPGTPase HRas/0.472
4dlxGNPGTPase HRas/0.472
4xoiGTPTransforming protein RhoA/0.472
1m7bGTPRho-related GTP-binding protein RhoE/0.471
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.471
3tgpGNPGTPase HRas/0.471
3kudGDPGTPase HRas/0.470
4dlvGNPGTPase HRas/0.470
4hdqGNPRas-related protein Rap-1b/0.470
4lhwGNPRas-related protein Rab-8A/0.469
4cymGCPRas-related protein Rab-32/0.468
3kkqGDPRas-related protein M-Ras/0.467
4dlzGNPGTPase HRas/0.467
1zc3GNPRas-related protein Ral-A/0.465
4l9sGDPGTPase HRas/0.465
4wa7GDPGTPase KRas/0.464
3akm11DFatty acid-binding protein, intestinal/0.463
4xvqGNPGTPase HRas/0.463
1a2bGSPTransforming protein RhoA/0.462
4l9wGNPGTPase HRas/0.461
1x1rGDPRas-related protein M-Ras/0.460
3dr7GPDGDP-perosamine synthase/0.460
4xbfFADLysine-specific histone demethylase 1A10.460
3cphGDPRas-related protein SEC4/0.458
1n6lGTPRas-related protein Rab-5A/0.457
4lpkGDPGTPase KRas/0.457
2fg5GNPRas-related protein Rab-31/0.456
4dsoGSPGTPase KRas/0.456
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.455
3tsoGNPRas-related protein Rab-25/0.454
4xvrGNPGTPase HRas/0.452
1oixGDPRas-related protein Rab-11A/0.450
1yu9GNPRas-related protein Rab-4A/0.450
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.449
1z0aGDPRas-related protein Rab-2A/0.448
2clsGTPRho-related GTP-binding protein Rho6/0.448
3bc1GNPRas-related protein Rab-27A/0.447
1g16GDPRas-related protein SEC4/0.445
2ic5GNPRas-related C3 botulinum toxin substrate 3/0.445
3pqbVGPPutative oxidoreductase/0.444
4q03GDPGTPase KRas/0.444
2ce2GDPGTPase HRas/0.443
2j3qTFLAcetylcholinesterase3.1.1.70.442
3ipuO40Oxysterols receptor LXR-alpha/0.440
4e2zJHZMethyltransferase/0.440
4epwGDPGTPase KRas/0.440
4lv6GDPGTPase KRas/0.440