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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4o25GTPGTP-binding protein Rheb

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4o25GTPGTP-binding protein Rheb/1.000
3e5hGNPRas-related protein Rab-28/0.606
3oesGNPGTPase RhebL1/0.590
1yzqGNPRas-related protein Rab-6A/0.584
1zbdGTPRas-related protein Rab-3A/0.576
1xtsGTPGTP-binding protein Rheb/0.570
1t91GTPRas-related protein Rab-7a/0.568
4qxaGTPRas-related protein Rab-9A/0.553
1yhnGTPRas-related protein Rab-7a/0.548
4rkfGNPRas-related protein Rab-3/0.548
5dhaGNPGTP-binding nuclear protein Ran/0.548
3bbpGTPRas-related protein Rab-6A/0.546
2gilGTPRas-related protein Rab-6A/0.544
3lawGNPRas-related protein Rab-7a/0.542
2fe4GDPRas-related protein Rab-6B/0.540
1vg8GNPRas-related protein Rab-7a/0.536
1xtrGNPGTP-binding protein Rheb/0.536
3tsoGNPRas-related protein Rab-25/0.536
2ffqGSPRas-related protein Rab-6B/0.533
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.532
3v4fGNPGTPase HRas/0.529
3lbnGNPGTPase HRas/0.521
3bc1GNPRas-related protein Rab-27A/0.516
3w3zGTPGTP-binding nuclear protein Ran/0.514
3rs5GNPGTPase HRas/0.513
2zetGTPRas-related protein Rab-27B/0.511
3nbzGTPGTP-binding nuclear protein Ran/0.510
3ea5GDPGTP-binding nuclear protein Ran/0.508
3rabGNPRas-related protein Rab-3A/0.508
4lhwGNPRas-related protein Rab-8A/0.508
1kmqGNPTransforming protein RhoA/0.505
1g17GNPRas-related protein SEC4/0.504
1k5dGNPGTP-binding nuclear protein Ran/0.504
4kvgGTPRas-related protein Rap-1A/0.504
1zc3GNPRas-related protein Ral-A/0.503
1e96GTPRas-related C3 botulinum toxin substrate 1/0.502
1lfdGNPGTPase HRas/0.501
3oiuGNPGTPase HRas/0.501
3ddcGNPGTPase HRas/0.498
4cymGCPRas-related protein Rab-32/0.498
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.496
3oivGNPGTPase HRas/0.495
5jljGNPGTP-binding nuclear protein Ran/0.495
2c5lGTPGTPase HRas/0.494
1ibrGNPGTP-binding nuclear protein Ran/0.492
3tnfGNPRas-related protein Rab-8A/0.490
4nyjGNPGTPase HRas/0.490
2bkuGTPGTP-binding nuclear protein Ran/0.489
3i3sGNPGTPase HRas/0.489
4nyiGNPGTPase HRas/0.489
3kudGDPGTPase HRas/0.488
4ol0GTPGTP-binding nuclear protein Ran/0.487
5hpyGDPTransforming protein RhoA/0.487
1s1cGNPTransforming protein RhoA/0.486
3cphGDPRas-related protein SEC4/0.485
4k81GTPGTPase HRas/0.483
2rgeGNPGTPase HRas/0.482
3eg5GNPCell division control protein 42 homolog/0.482
1oixGDPRas-related protein Rab-11A/0.481
3l8yGNPGTPase HRas/0.481
1zc4GNPRas-related protein Ral-A/0.480
4js0GNPCell division control protein 42 homolog/0.480
5c46GSPRas-related protein Rab-11A/0.480
3pitGNPRas-related protein M-Ras/0.478
4dltGNPGTPase HRas/0.476
1a2bGSPTransforming protein RhoA/0.475
1ow3GDPTransforming protein RhoA/0.474
2rgcGNPGTPase HRas/0.473
3a6pGTPGTP-binding nuclear protein Ran/0.471
1zd9GDPADP-ribosylation factor-like protein 8A/0.470
4uj5GNPRas-related protein Rab-11A/0.470
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.468
1uadGNPRas-related protein Ral-A/0.467
3a58GNPGTP-binding protein RHO1/0.467
4tyqAP5Adenylate kinase/0.467
3tklGTPRas-related protein Rab-1A/0.465
3rs0GNPGTPase HRas/0.464
3wqmB29Diterpene synthase3.1.7.80.463
4dlwGNPGTPase HRas/0.463
4mitGTPRho-related protein racC/0.463
4oi2ADPProtein clpf-1/0.463
5b2zGNPGTPase HRas/0.463
1z2cGNPRho-related GTP-binding protein RhoC/0.462
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.461
1cxzGSPTransforming protein RhoA/0.460
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.460
3kucGDPRas-related protein Rap-1A/0.457
4hdoGNPRas-related protein Rap-1b/0.453
3oiwGNPGTPase HRas/0.452
4uj3GNPRas-related protein Rab-11A/0.452
2gcpGSPRho-related GTP-binding protein RhoC/0.451
4dxaGSPRas-related protein Rap-1b/0.451
3kz1GSPTransforming protein RhoA/0.450
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.447
4ohxADPProtein clpf-1/0.444
4xvrGNPGTPase HRas/0.444
4xoiGTPTransforming protein RhoA/0.443
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.442
3th5GNPRas-related C3 botulinum toxin substrate 1/0.442
4tq9GDPGTPase KRas/0.441
3k8yGNPGTPase HRas/0.440