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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4nifANPMitogen-activated protein kinase 12.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4nifANPMitogen-activated protein kinase 12.7.11.241.000
4h3qANPMitogen-activated protein kinase 12.7.11.240.614
2y9qANPMitogen-activated protein kinase 12.7.11.240.542
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.502
4fv6E57Mitogen-activated protein kinase 12.7.11.240.493
4fmqANPMitogen-activated protein kinase 12.7.11.240.477
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.457
3nieANPMitogen-activated protein kinase/0.453
4s34ANPMitogen-activated protein kinase 12.7.11.240.449
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.443
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.442
3c4zADPRhodopsin kinase/0.441