sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 1.000 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.632 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.474 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.473 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.465 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.464 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.464 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.463 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.463 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.463 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.459 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.458 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.455 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.454 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.454 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.453 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.451 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.451 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.451 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.451 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.451 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.449 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.448 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.448 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.448 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.448 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.448 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.447 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.446 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.446 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.446 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.446 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.446 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.446 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.445 | |
| 2ejz | SAH | Diphthine synthase | / | 0.445 | |
| 2ok7 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.444 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.443 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.443 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.441 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.441 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.441 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.440 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.440 |