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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4lopSB4Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4lopSB4Mitogen-activated protein kinase 14/1.000
4loqSB4Mitogen-activated protein kinase 14/0.731
3hl7I47Mitogen-activated protein kinase 14/0.577
4looSB4Mitogen-activated protein kinase 14/0.534
3nww3NWMitogen-activated protein kinase 14/0.523
4aacAAVMitogen-activated protein kinase 14/0.513
3fln3FNMitogen-activated protein kinase 14/0.512
3hllI45Mitogen-activated protein kinase 14/0.497
3fklFKLMitogen-activated protein kinase 14/0.496
3gubGUBDeath-associated protein kinase 12.7.11.10.496
3fmh533Mitogen-activated protein kinase 14/0.491
1yw2PGJMitogen-activated protein kinase 14/0.488
3dt1P40Mitogen-activated protein kinase 14/0.487
4aa5NQBMitogen-activated protein kinase 14/0.486
4kin1M8Mitogen-activated protein kinase 14/0.486
2balPQAMitogen-activated protein kinase 14/0.483
3s4qNK0Mitogen-activated protein kinase 14/0.480
3fmkFMKMitogen-activated protein kinase 14/0.479
3flyFLYMitogen-activated protein kinase 14/0.478
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.476
4aa4QC0Mitogen-activated protein kinase 14/0.475
4nk92K5Fibroblast growth factor receptor 1/0.474
3flwFLWMitogen-activated protein kinase 14/0.473
3roc29AMitogen-activated protein kinase 14/0.473
3mvl38PMitogen-activated protein kinase 14/0.470
3flzFLZMitogen-activated protein kinase 14/0.469
3hvcGG5Mitogen-activated protein kinase 14/0.469
3iphG11Mitogen-activated protein kinase 14/0.469
2ghlLIBMitogen-activated protein kinase 14/0.468
3fi4FI4Mitogen-activated protein kinase 14/0.468
3fskRO6Mitogen-activated protein kinase 14/0.467
3uyt0CKCasein kinase I isoform delta2.7.11.10.467
3kf7L9GMitogen-activated protein kinase 14/0.466
3s85LK0Gag-Pol polyprotein/0.465
1k6pXN3Gag-Pol polyprotein3.4.23.160.464
2xikJ60Serine/threonine-protein kinase 252.7.11.10.464
3uzp0CKCasein kinase I isoform delta2.7.11.10.464
4qmzB49Serine/threonine-protein kinase 242.7.11.10.464
1di8DTQCyclin-dependent kinase 22.7.11.220.462
1k6cMK1Gag-Pol polyprotein3.4.23.160.460
4kiq1RAMitogen-activated protein kinase 14/0.459
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.457
1ouk084Mitogen-activated protein kinase 14/0.456
2c475IDCasein kinase I isoform gamma-2/0.456
3mpaSB2Mitogen-activated protein kinase 14/0.456
1hosPHPGag-Pol polyprotein/0.454
1t7i017Gag-Pol polyprotein3.4.23.160.454
1k6vXN2Gag-Pol polyprotein3.4.23.160.451
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.451
4fod0UVALK tyrosine kinase receptor2.7.10.10.451
5dp2NAPCurF/0.451
1u4dDBQActivated CDC42 kinase 1/0.450
3a2oKNJGag-Pol polyprotein3.4.23.160.450
4kip1R9Mitogen-activated protein kinase 14/0.450
4l9kEHFSerum albumin/0.450
1zz2B11Mitogen-activated protein kinase 14/0.449
3ggxGGXGag-Pol polyprotein/0.449
3ttiKBIMitogen-activated protein kinase 102.7.11.240.449
2iw84SPCyclin-dependent kinase 22.7.11.220.448
2rg5279Mitogen-activated protein kinase 14/0.448
3bgbLJGGag-Pol polyprotein3.4.23.160.447
3t3c017Gag-Pol polyprotein3.4.23.160.447
4f650S9Fibroblast growth factor receptor 1/0.447
3nu4478Gag-Pol polyprotein3.4.23.160.446
5aacVGHALK tyrosine kinase receptor2.7.10.10.446
1c6yMK1Protease/0.445
3nu5478Gag-Pol polyprotein3.4.23.160.445
3qp0NI8Gag-Pol polyprotein3.4.23.160.445
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.445
4yuqKS1Calmodulin-like domain protein kinase/0.445
5e8wSTUTGF-beta receptor type-12.7.11.300.445
1k6tXN1Gag-Pol polyprotein3.4.23.160.444
2rkfAB1Pol protein/0.444
3u8w09JMitogen-activated protein kinase 14/0.444
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.444
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.444
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.444
1msmJE2Gag-Pol polyprotein3.4.23.160.443
3nwxKVSGag-Pol polyprotein3.4.23.160.443
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.443
3bgcLJHGag-Pol polyprotein3.4.23.160.442
3d1xROCGag-Pol polyprotein3.4.23.160.442
3gxlQIGTGF-beta receptor type-12.7.11.300.442
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.442
3s43478Protease/0.442
4ewqMWLMitogen-activated protein kinase 14/0.442
4kb81QOCasein kinase I isoform delta2.7.11.10.442
4uymVOR14-alpha sterol demethylase Cyp51B/0.442
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1sh9RITGag-Pol polyprotein3.4.23.160.441
1vikBAYGag-Pol polyprotein/0.441
2c6tDT5Cyclin-dependent kinase 22.7.11.220.441
2x1nX1NCyclin-dependent kinase 22.7.11.220.441
4ye3G04Gag-Pol polyprotein3.4.23.160.441
1ywrLI9Mitogen-activated protein kinase 14/0.440
2q5kAB1Protease/0.440
3a7jADPSerine/threonine-protein kinase 242.7.11.10.440
3c4zADPRhodopsin kinase/0.440
3oy4017Gag-Pol polyprotein3.4.23.160.440
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.440
4ih8B43Calmodulin-domain protein kinase 1/0.440