sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4l64 | C2F | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase | 2.1.1.14 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4l64 | C2F | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase | 2.1.1.14 | 1.000 | |
| 1u1j | C2F | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 | 2.1.1.14 | 0.586 | |
| 4l65 | C2F | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase | 2.1.1.14 | 0.545 | |
| 1u22 | THG | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 | 2.1.1.14 | 0.485 | |
| 3zoz | ADP | Phosphoglycerate kinase 1 | 2.7.2.3 | 0.474 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.462 | |
| 1qnf | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.459 | |
| 1wbp | ADP | SRSF protein kinase 1 | 2.7.11.1 | 0.456 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.452 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.449 | |
| 5c7o | NAD | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | 1.2.1.12 | 0.449 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4k5e | 1Q7 | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.445 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 2xy9 | 3ES | Angiotensin-converting enzyme | 3.2.1 | 0.440 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.440 | |
| 4ktt | SAM | S-adenosylmethionine synthase isoform type-2 | 2.5.1.6 | 0.440 |