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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4l455FIRibosomal protein S6 kinase beta-12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4l455FIRibosomal protein S6 kinase beta-12.7.11.11.000
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.580
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.542
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.524
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.516
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.515
4l445FIRibosomal protein S6 kinase beta-12.7.11.10.504
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.498
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.493
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.481
4otiMI1Serine/threonine-protein kinase N1/0.474
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.463
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4bbe3O4Tyrosine-protein kinase JAK2/0.457
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.456
4bbfO19Tyrosine-protein kinase JAK2/0.456
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2etrY27Rho-associated protein kinase 12.7.11.10.448
3t113T1Gag-Pol polyprotein3.4.23.160.448
1k6cMK1Gag-Pol polyprotein3.4.23.160.447
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2fxdDR7Pol polyprotein/0.443
4bcmT7ZCyclin-dependent kinase 22.7.11.220.443
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.443
1k6tXN1Gag-Pol polyprotein3.4.23.160.441
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.441
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3a8wATPProtein kinase C iota type2.7.11.130.440
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.440
3orpAGSSerine/threonine protein kinase/0.440