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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/1.000
1f123HCHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.519
4yryFADGlutamate synthase, beta subunit/0.473
3kpkFADSulfide-quinone reductase/0.466
1yb5NAPQuinone oxidoreductase1.6.5.50.461
3b6zCO7Enoyl reductase LovC10.461
4g7gVFVLanosterol 14-alpha-demethylase/0.456
2dteNAIGlucose 1-dehydrogenase related protein/0.454
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
3jzdNADMaleylacetate reductase/0.452
3t14FADSulfide-quinone reductase/0.452
4jjiNADAlcohol dehydrogenase class-3/0.450
2ebaFADPutative glutaryl-CoA dehydrogenase/0.448
3t2kFADSulfide-quinone reductase/0.448
2ignFADPyranose 2-oxidase/0.447
2fzwNADAlcohol dehydrogenase class-31.1.1.10.445
2y0mACOHistone acetyltransferase KAT8/0.445
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.444
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.444
3t2zFADSulfide-quinone reductase/0.444
4g3jVNTLanosterol 14-alpha-demethylase/0.444
3bgbLJGGag-Pol polyprotein3.4.23.160.443
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.443
3sz0FADSulfide-quinone reductase/0.442
3dmeFADPutative conserved exported protein/0.441
3ol5SAWCamphor 5-monooxygenase1.14.15.10.441
4a6bQG8Gag-Pol polyprotein3.4.23.160.441
1d4jMSCGag-Pol polyprotein3.4.23.160.440
1lj8NADMannitol dehydrogenase/0.440
1npvL27Gag-Pol polyprotein3.4.23.160.440
2yltFADPhenylacetone monooxygenase1.14.13.920.440
3ekp478Gag-Pol polyprotein3.4.23.160.440
3gw9VNILanosterol 14-alpha-demethylase/0.440
3owaFADAcyl-CoA dehydrogenase/0.440
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440