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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4kmzFOLFolate receptor beta

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4kmzFOLFolate receptor beta/1.000
4kn0MTXFolate receptor beta/0.617
4kn104JFolate receptor beta/0.614
4lrhFOLFolate receptor alpha/0.596
4kn2LYAFolate receptor beta/0.568
2f3815MAldo-keto reductase family 1 member C3/0.487
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.472
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.470
2aouCQAHistamine N-methyltransferase2.1.1.80.470
4arbC57Acetylcholinesterase3.1.1.70.470
1s36CEIObelin/0.469
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.468
4bj9UHBTankyrase-22.4.2.300.468
1t40ID5Aldose reductase1.1.1.210.464
2aot2PMHistamine N-methyltransferase2.1.1.80.464
4li61XOTankyrase-12.4.2.300.464
1ry0PG2Aldo-keto reductase family 1 member C3/0.463
1z8962PAldose reductase1.1.1.210.462
4jpg1OXPyruvate kinase PKM2.7.1.400.461
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.460
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.460
2cekN8TAcetylcholinesterase3.1.1.70.459
2ikj393Aldose reductase1.1.1.210.458
3f3y4OABile salt sulfotransferase2.8.2.140.458
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.457
2vqqTFGHistone deacetylase 43.5.1.980.456
2dv0ZSTAldose reductase1.1.1.210.455
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.455
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.453
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.453
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.453
1z3n3NAAldose reductase1.1.1.210.452
3ugrIMNAldo-keto reductase family 1 member C3/0.452
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.452
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.452
4yfy0FXVioF/0.451
2hv5ZSTAldose reductase1.1.1.210.450
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.450
2wu4HBPAcetylcholinesterase3.1.1.70.450
3ny8JRZBeta-2 adrenergic receptor/0.450
4fam0SZAldo-keto reductase family 1 member C3/0.449
4gbrCAUBeta-2 adrenergic receptor/0.449
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.448
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.448
2pdbZSTAldose reductase1.1.1.210.447
2ycwCAUBeta-1 adrenergic receptor/0.447
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.447
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.447
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
1xf0ASDAldo-keto reductase family 1 member C3/0.446
3mb9ZSTAldose reductase1.1.1.210.446
1hfrMOTDihydrofolate reductase1.5.1.30.445
2pdxZSTAldose reductase1.1.1.210.445
3b82NADExotoxin A2.4.2.360.445
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.445
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.445
1w6jR71Lanosterol synthase5.4.99.70.444
1ry8RUTAldo-keto reductase family 1 member C3/0.443
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.443
2xujTZ5Acetylcholinesterase3.1.1.70.443
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.443
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.443
2y0468HBeta-1 adrenergic receptor/0.443
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.442
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.442
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.442
2pdmZSTAldose reductase1.1.1.210.442
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.442
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.442
2fz8ZSTAldose reductase1.1.1.210.441
2fz9ZSTAldose reductase1.1.1.210.441
3uweVJJAldo-keto reductase family 1 member C3/0.441
4hyf1AKTankyrase-22.4.2.300.441
1rvvINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
1zgcA2EAcetylcholinesterase3.1.1.70.440
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.440
2zs9ADPPantothenate kinase2.7.1.330.440
3gsiTHGDimethylglycine oxidase1.5.3.100.440
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.440
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.440
4dbuBT9Aldo-keto reductase family 1 member C3/0.440