Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4kiq1RAMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4kiq1RAMitogen-activated protein kinase 14/1.000
4aacAAVMitogen-activated protein kinase 14/0.620
4aa5NQBMitogen-activated protein kinase 14/0.609
4aa4QC0Mitogen-activated protein kinase 14/0.582
3fklFKLMitogen-activated protein kinase 14/0.581
3nww3NWMitogen-activated protein kinase 14/0.554
4kip1R9Mitogen-activated protein kinase 14/0.553
3hl7I47Mitogen-activated protein kinase 14/0.551
3fln3FNMitogen-activated protein kinase 14/0.550
3s4qNK0Mitogen-activated protein kinase 14/0.545
3iphG11Mitogen-activated protein kinase 14/0.543
3ocgOCGMitogen-activated protein kinase 14/0.533
2balPQAMitogen-activated protein kinase 14/0.532
3mvl38PMitogen-activated protein kinase 14/0.531
3mpt1GKMitogen-activated protein kinase 14/0.524
2rg5279Mitogen-activated protein kinase 14/0.517
3flwFLWMitogen-activated protein kinase 14/0.514
4lopSB4Mitogen-activated protein kinase 14/0.513
4kin1M8Mitogen-activated protein kinase 14/0.512
3dt1P40Mitogen-activated protein kinase 14/0.510
3fskRO6Mitogen-activated protein kinase 14/0.510
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.509
2rg6287Mitogen-activated protein kinase 14/0.505
3fmh533Mitogen-activated protein kinase 14/0.501
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.500
3fmkFMKMitogen-activated protein kinase 14/0.496
1zyjBI5Mitogen-activated protein kinase 14/0.495
3flyFLYMitogen-activated protein kinase 14/0.495
3fi4FI4Mitogen-activated protein kinase 14/0.493
3uvqFS8Mitogen-activated protein kinase 14/0.492
3w33W19Epidermal growth factor receptor2.7.10.10.492
4loqSB4Mitogen-activated protein kinase 14/0.492
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.490
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.490
4looSB4Mitogen-activated protein kinase 14/0.488
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.486
3l8xN4DMitogen-activated protein kinase 14/0.485
1zz2B11Mitogen-activated protein kinase 14/0.482
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.482
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.481
3flzFLZMitogen-activated protein kinase 14/0.481
3hvcGG5Mitogen-activated protein kinase 14/0.480
3u8w09JMitogen-activated protein kinase 14/0.480
3uyt0CKCasein kinase I isoform delta2.7.11.10.480
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.475
1py5PY1TGF-beta receptor type-12.7.11.300.474
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.473
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.473
4ic7ANPMitogen-activated protein kinase 72.7.11.240.473
3zh8C58Protein kinase C iota type2.7.11.130.472
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.471
3vs3VSETyrosine-protein kinase HCK2.7.10.20.471
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.471
3vryB43Tyrosine-protein kinase HCK2.7.10.20.470
3gubGUBDeath-associated protein kinase 12.7.11.10.469
3mvm39PMitogen-activated protein kinase 14/0.469
4i22IREEpidermal growth factor receptor2.7.10.10.468
2ghlLIBMitogen-activated protein kinase 14/0.467
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.467
4b99R4LMitogen-activated protein kinase 72.7.11.240.467
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.466
3hllI45Mitogen-activated protein kinase 14/0.466
4dpwAGSMevalonate diphosphate decarboxylase/0.465
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.464
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.461
3zuyTCHTransporter/0.461
4dymIYZActivin receptor type-12.7.11.300.461
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.460
4riyADPEpidermal growth factor receptor2.7.10.10.460
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
1u4dDBQActivated CDC42 kinase 1/0.457
3gfeP37Mitogen-activated protein kinase 14/0.456
2itpAEEEpidermal growth factor receptor2.7.10.10.455
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.455
3vs1VSATyrosine-protein kinase HCK2.7.10.20.455
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.455
1m17AQ4Epidermal growth factor receptor2.7.10.10.454
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.454
1v0pPVBCell division control protein 2 homolog2.7.11.220.454
3uvp048Mitogen-activated protein kinase 14/0.454
2itnANPEpidermal growth factor receptor2.7.10.10.453
3roc29AMitogen-activated protein kinase 14/0.453
1ywrLI9Mitogen-activated protein kinase 14/0.452
1vjy460TGF-beta receptor type-12.7.11.300.451
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.451
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.451
4jq8KJ8Epidermal growth factor receptor2.7.10.10.451
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.451
3b6zCO7Enoyl reductase LovC10.450
1gteFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.449
1h7wFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.449
1k6cMK1Gag-Pol polyprotein3.4.23.160.449
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.449
2y6o1N1Ephrin type-A receptor 42.7.10.10.449
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.449
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.449
4fv9E71Mitogen-activated protein kinase 12.7.11.240.449
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.449
2wotZZGTGF-beta receptor type-12.7.11.300.448
3gc9B45Mitogen-activated protein kinase 112.7.11.240.448
3vjoANPEpidermal growth factor receptor2.7.10.10.448
4fob0USALK tyrosine kinase receptor2.7.10.10.448
4jr3KJREpidermal growth factor receptor2.7.10.10.448
1unlRRCCyclin-dependent-like kinase 52.7.11.10.447
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.447
4nk92K5Fibroblast growth factor receptor 1/0.447
2wouZZFTGF-beta receptor type-12.7.11.300.446
3ac2KSETyrosine-protein kinase Lck2.7.10.20.446
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.446
4gk3L87Ephrin type-A receptor 32.7.10.10.446
4hjoAQ4Epidermal growth factor receptor2.7.10.10.446
4iaq2GM5-hydroxytryptamine receptor 1B/0.446
4kb81QOCasein kinase I isoform delta2.7.11.10.446
3qakUKAAdenosine receptor A2a/0.446
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.445
4bgg844Activin receptor type-12.7.11.300.445
4gk2L66Ephrin type-A receptor 32.7.10.10.445
1xkkFMMEpidermal growth factor receptor2.7.10.10.444
2ittAEEEpidermal growth factor receptor2.7.10.10.444
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.444
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
3gstGPRGlutathione S-transferase Mu 12.5.1.180.444
4hnf16WCasein kinase I isoform delta2.7.11.10.444
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.443
2qo9ANPEphrin type-A receptor 32.7.10.10.443
2x3nFADProbable FAD-dependent monooxygenase/0.443
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.443
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.443
1fm4DXCMajor pollen allergen Bet v 1-L/0.442
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.442
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.442
1bygSTUTyrosine-protein kinase CSK/0.441
2oji33AMitogen-activated protein kinase 12.7.11.240.441
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.441
1k6pXN3Gag-Pol polyprotein3.4.23.160.440
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.440
2qd9LGFMitogen-activated protein kinase 14/0.440
3gu83GUDeath-associated protein kinase 12.7.11.10.440
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.440
3tqhNDPQuinone oxidoreductase/0.440
3w32W32Epidermal growth factor receptor2.7.10.10.440
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.440