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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.25

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.251.000
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.250.480
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.448
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.446
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.440
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.440