sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 1.000 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.550 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.513 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.510 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.482 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.479 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.473 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.472 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.469 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.466 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.465 | |
| 4a95 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.461 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.460 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.458 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 5dp2 | NAP | CurF | / | 0.456 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 4a2z | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.455 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.452 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.451 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4b13 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.448 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.448 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.448 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.448 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.447 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.445 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.445 | |
| 1eio | GCH | Gastrotropin | / | 0.444 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.444 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.443 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.443 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.443 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.442 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.442 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.441 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 4a30 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4b10 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4iae | 1DX | Alr2278 protein | / | 0.440 |