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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fizCUE17beta-hydroxysteroid dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fizCUE17beta-hydroxysteroid dehydrogenase/1.000
3qe2FMNNADPH--cytochrome P450 reductase/0.471
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.468
4fj1GEN17beta-hydroxysteroid dehydrogenase/0.468
3qwiCUE17beta-hydroxysteroid dehydrogenase/0.465
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
4g7gVFVLanosterol 14-alpha-demethylase/0.459
3d91REMRenin3.4.23.150.454
3g72A6TRenin3.4.23.150.453
3oadLPORenin3.4.23.150.452
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.450
4g3jVNTLanosterol 14-alpha-demethylase/0.449
3g70A5TRenin3.4.23.150.448
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.446
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.445
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.445
3gw9VNILanosterol 14-alpha-demethylase/0.445
3vsxR32Renin3.4.23.150.445
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
2xytTC9Soluble acetylcholine receptor/0.443
3hl0NADMaleylacetate reductase/0.443
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.443
4frkDWDBeta-secretase 13.4.23.460.443
2il2LIXRenin3.4.23.150.440