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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fgzSAHPhosphoethanolamine N-methyltransferase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fgzSAHPhosphoethanolamine N-methyltransferase/1.000
3uj7SAMPhosphoethanolamine N-methyltransferase/0.640
3uj8SFGPhosphoethanolamine N-methyltransferase/0.608
4iv0SAMPhosphoethanolamine N-methyltransferase, putative/0.573
4r6xSAHPhosphoethanolamine N-methyltransferase/0.573
4iv8SAMPhosphoethanolamine N-methyltransferase,putative/0.551
4mwzSAMPhosphoethanolamine N-methyltransferase, putative/0.546
4krhSAMPhosphoethanolamine N-methyltransferase 2/0.532
5epeSAHUncharacterized protein/0.480
5bp7SAHSAM-dependent methyltransferase/0.476
5bw4SAMUncharacterized protein/0.467
1n06ADPRiboflavin kinase2.7.1.260.464
3tljSAHUncharacterized protein/0.463
1kphSAHCyclopropane mycolic acid synthase 12.1.1.790.462
3ha3SAHHydroxymycolate synthase MmaA42.1.10.462
4necSAHPutative SAM-dependent methyltransferase/0.458
4qtuSAM18S rRNA (guanine(1575)-N(7))-methyltransferase/0.458
5icfSAH(S)-norcoclaurine 6-O-methyltransferase/0.454
2fk8SAMHydroxymycolate synthase MmaA42.1.10.453
3ha5SFGHydroxymycolate synthase MmaA42.1.10.453
2xynVX6Abelson tyrosine-protein kinase 22.7.10.20.452
2y05NAPProstaglandin reductase 1/0.450
4f86SFGGeranyl diphosphate 2-C-methyltransferase2.1.1.2550.450
3b3fSAHHistone-arginine methyltransferase CARM1/0.449
2bb9AKCGag-Pol polyprotein3.4.23.160.448
1qanSAHrRNA adenine N-6-methyltransferase2.1.1.1840.446
3kpjSAHPhenylethanolamine N-methyltransferase2.1.1.280.444
3vey0H5Glucokinase2.7.1.20.444
5je4SAHMethyl transferase/0.444
1sg9SAMRelease factor glutamine methyltransferase2.1.1.2970.443
4h1vGNPDynamin-1-like protein3.6.5.50.442
3a9wNADNDP-sugar epimerase/0.440
3cjqSAHRibosomal protein L11 methyltransferase2.1.10.440