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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4f6w0SSCyclin-dependent kinase 82.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4f6w0SSCyclin-dependent kinase 82.7.11.221.000
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.462
4f7l0SOCyclin-dependent kinase 82.7.11.220.459
4q71FADBifunctional protein PutA/0.457
4f700STCyclin-dependent kinase 82.7.11.220.454
2v59LZKBiotin carboxylase6.3.4.140.449
1drhNAPDihydrofolate reductase1.5.1.30.448
4rvfTYDD-mycarose 3-C-methyltransferase/0.447
4s0vSUVOrexin receptor type 2/0.446
1adfTADAlcohol dehydrogenase E chain1.1.1.10.445
4q73FADBifunctional protein PutA/0.445
1m78NDPDihydrofolate reductase1.5.1.30.443
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.443
3kb6NADD-lactate dehydrogenase/0.442
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.441
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.441
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440