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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4e6q0NVTyrosine-protein kinase JAK2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4e6q0NVTyrosine-protein kinase JAK2/1.000
4e4n0NLTyrosine-protein kinase JAK1/0.539
4hge15VTyrosine-protein kinase JAK2/0.515
4e6d0NUTyrosine-protein kinase JAK2/0.504
1qmzATPCyclin-dependent kinase 22.7.11.220.490
4aqc88ATyrosine-protein kinase JAK2/0.490
3lpbNVBTyrosine-protein kinase JAK2/0.486
5eg3ACPFibroblast growth factor receptor 2/0.486
4i5cC5ITyrosine-protein kinase JAK1/0.476
4ivb1J5Tyrosine-protein kinase JAK1/0.474
4ii5ADPCyclin-dependent kinase 22.7.11.220.472
4bbfO19Tyrosine-protein kinase JAK2/0.469
4ji91M3Tyrosine-protein kinase JAK2/0.469
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.468
4hvi19STyrosine-protein kinase JAK32.7.10.20.468
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.465
4qnyANPMitogen activated protein kinase, putative/0.461
4z34ON7Lysophosphatidic acid receptor 1/0.460
4ehzJAKTyrosine-protein kinase JAK1/0.459
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.458
4e5w0NTTyrosine-protein kinase JAK1/0.457
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.455
3orpAGSSerine/threonine protein kinase/0.454
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
4z35ON9Lysophosphatidic acid receptor 1/0.448
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.445
4i3zADPCyclin-dependent kinase 22.7.11.220.445
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.442
4gt3ATPMitogen-activated protein kinase 12.7.11.240.442
1yvj4STTyrosine-protein kinase JAK32.7.10.20.441