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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4e5w0NTTyrosine-protein kinase JAK1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4e5w0NTTyrosine-protein kinase JAK1/1.000
4e4n0NLTyrosine-protein kinase JAK1/0.507
4e6d0NUTyrosine-protein kinase JAK2/0.506
4i5cC5ITyrosine-protein kinase JAK1/0.506
4fk60UJTyrosine-protein kinase JAK1/0.499
4ehzJAKTyrosine-protein kinase JAK1/0.498
4ivb1J5Tyrosine-protein kinase JAK1/0.497
4aqc88ATyrosine-protein kinase JAK2/0.494
4f081RSTyrosine-protein kinase JAK2/0.484
4ei40Q2Tyrosine-protein kinase JAK1/0.469
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.468
4fv6E57Mitogen-activated protein kinase 12.7.11.240.466
4ivc1J6Tyrosine-protein kinase JAK1/0.464
4e6q0NVTyrosine-protein kinase JAK2/0.460
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.460
4k771Q4Tyrosine-protein kinase JAK1/0.453
3s1h56ZCyclin-dependent kinase 22.7.11.220.451
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.448
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
1qmzATPCyclin-dependent kinase 22.7.11.220.447
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.446
4qnyANPMitogen activated protein kinase, putative/0.446
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.445
1g5sI17Cyclin-dependent kinase 22.7.11.220.440
4ji91M3Tyrosine-protein kinase JAK2/0.440