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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dz5NAPAldo-keto reductase family 1 member C3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dz5NAPAldo-keto reductase family 1 member C3/1.000
1s1rNAPAldo-keto reductase family 1 member C3/0.664
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.575
2hdjNDPAldo-keto reductase family 1 member C2/0.553
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.553
4xo7NAPAldo-keto reductase family 1 member C2/0.552
4l1xNAPAldo-keto reductase family 1 member C2/0.541
4jq3NAPAldo-keto reductase family 1 member C2/0.539
4jtqNAPAldo-keto reductase family 1 member C2/0.534
1s1pNAPAldo-keto reductase family 1 member C3/0.530
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.530
3h7rNAPAldo-keto reductase family 4 member C8/0.519
2hejNDPAldo-keto reductase family 1 member C211.1.10.513
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.510
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.507
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.504
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.504
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.496
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.474
1c9wNAPAldose reductase-related protein 2/0.472
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.469
3wczNAPAldo-keto reductase AKR2E4/0.466
3o3rNAPAldose reductase-related protein 11.1.1.210.462
4pmjNAPPutative oxidoreductase/0.459
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.457
3q65NAPAldose reductase1.1.1.210.453
1adsNAPAldose reductase1.1.1.210.451
5c7hNDPPutative oxidoreductase/0.450
1ah4NAPAldose reductase1.1.1.210.447
3v36NAPAldose reductase1.1.1.210.447
1x98NAPAldose reductase1.1.1.210.446
1zgdNAPChalcone reductase/0.446
2acqNAPAldose reductase1.1.1.210.445
1az2NAPAldose reductase1.1.1.210.444
1pz1NAPGeneral stress protein 69/0.444
3q67NAPAldose reductase1.1.1.210.444
3qkzNAPAldose reductase-related protein 11.1.1.210.443
1x96NAPAldose reductase1.1.1.210.442
2iq0NAPAldose reductase1.1.1.210.441
2j8tNAPAldose reductase1.1.1.210.440
2pevNDPAldose reductase1.1.1.210.440