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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dsnGCPGTPase KRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dsnGCPGTPase KRas/1.000
3pitGNPRas-related protein M-Ras/0.634
4g0nGNPGTPase HRas/0.622
3kkoGNPRas-related protein M-Ras/0.618
3ddcGNPGTPase HRas/0.615
4nyjGNPGTPase HRas/0.608
3lbhGNPGTPase HRas/0.603
3k8yGNPGTPase HRas/0.602
2rgeGNPGTPase HRas/0.601
3lbnGNPGTPase HRas/0.592
3lbiGNPGTPase HRas/0.591
3x1zGNPRas-related protein Rap-1b/0.589
3kucGDPRas-related protein Rap-1A/0.584
3v4fGNPGTPase HRas/0.584
2c5lGTPGTPase HRas/0.572
3oiuGNPGTPase HRas/0.572
3oivGNPGTPase HRas/0.572
2rgcGNPGTPase HRas/0.568
4hdoGNPRas-related protein Rap-1b/0.567
3e5hGNPRas-related protein Rab-28/0.566
4nyiGNPGTPase HRas/0.565
1cxzGSPTransforming protein RhoA/0.564
1zc4GNPRas-related protein Ral-A/0.564
3i3sGNPGTPase HRas/0.564
4dltGNPGTPase HRas/0.563
3l8yGNPGTPase HRas/0.561
4mitGTPRho-related protein racC/0.561
3rs5GNPGTPase HRas/0.560
3oesGNPGTPase RhebL1/0.559
3oiwGNPGTPase HRas/0.555
2gilGTPRas-related protein Rab-6A/0.553
3rs0GNPGTPase HRas/0.552
4dlxGNPGTPase HRas/0.552
4lhwGNPRas-related protein Rab-8A/0.552
2rgbGNPGTPase HRas/0.551
1zc3GNPRas-related protein Ral-A/0.550
3rs7GNPGTPase HRas/0.550
3w3zGTPGTP-binding nuclear protein Ran/0.550
3rs4GNPGTPase HRas/0.549
1zbdGTPRas-related protein Rab-3A/0.548
4dlzGNPGTPase HRas/0.548
4k81GTPGTPase HRas/0.546
5difGNPGTP-binding nuclear protein Ran/0.545
1kmqGNPTransforming protein RhoA/0.544
1xtsGTPGTP-binding protein Rheb/0.543
4ol0GTPGTP-binding nuclear protein Ran/0.543
1t91GTPRas-related protein Rab-7a/0.542
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.541
5b2zGNPGTPase HRas/0.540
1zd9GDPADP-ribosylation factor-like protein 8A/0.539
4dlwGNPGTPase HRas/0.538
2gcpGSPRho-related GTP-binding protein RhoC/0.534
3wyfGTPGTP-binding nuclear protein/0.534
1g17GNPRas-related protein SEC4/0.531
1xtrGNPGTP-binding protein Rheb/0.531
1yhnGTPRas-related protein Rab-7a/0.531
3a6pGTPGTP-binding nuclear protein Ran/0.531
3a58GNPGTP-binding protein RHO1/0.529
3bbpGTPRas-related protein Rab-6A/0.528
3rabGNPRas-related protein Rab-3A/0.528
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.528
1a2bGSPTransforming protein RhoA/0.527
1m7bGTPRho-related GTP-binding protein RhoE/0.527
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.526
5dhaGNPGTP-binding nuclear protein Ran/0.526
1e96GTPRas-related C3 botulinum toxin substrate 1/0.525
5jljGNPGTP-binding nuclear protein Ran/0.523
2msdGNPMHC class I alpha chain/0.522
4dlsGNPGTPase HRas/0.522
2bkuGTPGTP-binding nuclear protein Ran/0.521
3nbzGTPGTP-binding nuclear protein Ran/0.520
4lucGDPGTPase KRas/0.520
4dlvGNPGTPase HRas/0.519
1gwnGTPRho-related GTP-binding protein RhoE/0.517
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.517
3mjhGTPRas-related protein Rab-5A/0.517
3rslGNPGTPase HRas/0.516
4l9wGNPGTPase HRas/0.515
4tq9GDPGTPase KRas/0.515
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.514
2rggGNPGTPase HRas/0.514
3kudGDPGTPase HRas/0.514
2fe4GDPRas-related protein Rab-6B/0.512
4o2lGTPGTP-binding protein Rheb/0.511
4rkfGNPRas-related protein Rab-3/0.510
3lawGNPRas-related protein Rab-7a/0.509
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.507
3ea5GDPGTP-binding nuclear protein Ran/0.506
1yzqGNPRas-related protein Rab-6A/0.505
3tgpGNPGTPase HRas/0.503
3tnfGNPRas-related protein Rab-8A/0.500
4dsoGSPGTPase KRas/0.497
1z2aGDPRas-related protein Rab-23/0.496
4kvgGTPRas-related protein Rap-1A/0.496
1ibrGNPGTP-binding nuclear protein Ran/0.495
3kkqGDPRas-related protein M-Ras/0.495
4hdqGNPRas-related protein Rap-1b/0.494
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.493
2zetGTPRas-related protein Rab-27B/0.493
4xoiGTPTransforming protein RhoA/0.493
4epxGDPGTPase KRas/0.492
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.491
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.491
3x1wGDPRas-related protein Rap-1b/0.491
2mseGNPMHC class I alpha chain/0.490
4q03GDPGTPase KRas/0.488
1s1cGNPTransforming protein RhoA/0.487
4qxaGTPRas-related protein Rab-9A/0.487
4xvqGNPGTPase HRas/0.487
3kz1GSPTransforming protein RhoA/0.485
1d5cGDPGTPase (Rab6)/0.484
4lpkGDPGTPase KRas/0.483
3tsoGNPRas-related protein Rab-25/0.482
2ffqGSPRas-related protein Rab-6B/0.481
3k9lGNPGTPase HRas/0.481
4ql3GDPGTPase KRas/0.481
1yu9GNPRas-related protein Rab-4A/0.480
4l9sGDPGTPase HRas/0.479
4o25GTPGTP-binding protein Rheb/0.476
1k5dGNPGTP-binding nuclear protein Ran/0.475
4xvrGNPGTPase HRas/0.475
1ow3GDPTransforming protein RhoA/0.474
4uj3GNPRas-related protein Rab-11A/0.474
4wa7GDPGTPase KRas/0.474
3th5GNPRas-related C3 botulinum toxin substrate 1/0.473
4uj5GNPRas-related protein Rab-11A/0.473
4o2rGDPGTP-binding protein Rheb/0.472
4d0lGSPRas-related protein Rab-11A/0.471
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.470
4lv6GDPGTPase KRas/0.470
1n6lGTPRas-related protein Rab-5A/0.469
1tu3GNPRas-related protein Rab-5A/0.468
2ce2GDPGTPase HRas/0.468
2fg5GNPRas-related protein Rab-31/0.468
1vg8GNPRas-related protein Rab-7a/0.465
4dxaGSPRas-related protein Rap-1b/0.465
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.464
5c46GSPRas-related protein Rab-11A/0.463
3eg5GNPCell division control protein 42 homolog/0.461
4epwGDPGTPase KRas/0.461
1lfdGNPGTPase HRas/0.460
1uadGNPRas-related protein Ral-A/0.460
3qbtGNPRas-related protein Rab-8A/0.460
4l8gGDPGTPase KRas/0.459
2clsGTPRho-related GTP-binding protein Rho6/0.458
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.458
4ldjGDPGTPase KRas/0.458
4js0GNPCell division control protein 42 homolog/0.457
1g16GDPRas-related protein SEC4/0.456
4cymGCPRas-related protein Rab-32/0.456
4lrwGDPGTPase KRas/0.455
3cphGDPRas-related protein SEC4/0.454
1oixGDPRas-related protein Rab-11A/0.453
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.452
5hpyGDPTransforming protein RhoA/0.452
1z0aGDPRas-related protein Rab-2A/0.450
2j5xGSPADP-ribosylation factor 6/0.450
4q02GDPGTPase KRas/0.448
4iji99TGlutathione S-transferase-like protein YibF/0.447
1x1rGDPRas-related protein M-Ras/0.446
4obeGDPGTPase KRas/0.445
2bmeGNPRas-related protein Rab-4A/0.444
1v25ANPLong-chain-fatty-acid--CoA ligase6.2.1.30.442
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.440
4cidANPEH domain-containing protein 2/0.440