scPDB - Distribution of Binding site Similarity values of 4dp3 entry / Site 2

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	1.000
3cse	N22	Uncharacterized protein	/	0.583
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.567
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.561
3eek	53S	Uncharacterized protein	/	0.558
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.549
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.547
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.547
3qly	55V	Uncharacterized protein	/	0.546
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.545
3qlx	QLR	Uncharacterized protein	/	0.545
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.534
4h98	14Q	Uncharacterized protein	/	0.533
3eel	53T	Uncharacterized protein	/	0.529
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.523
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.522
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.514
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.513
3eem	53V	Uncharacterized protein	/	0.512
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.512
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.509
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.509
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.507
2w3v	TOP	Dihydrofolate reductase	/	0.506
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.505
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.505
3sai	9DR	Dihydrofolate reductase	/	0.502
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.498
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.493
3eej	53R	Uncharacterized protein	/	0.493
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.489
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.485
2w3w	VG9	Dihydrofolate reductase	/	0.485
4ddr	MMV	Dihydrofolate reductase	1.5.1.3	0.485
3rg9	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.483
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.480
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.479
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.478
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.478
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.477
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.477
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.476
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.476
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.476
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.476
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.475
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.474
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.473
2zza	FOL	Dihydrofolate reductase	/	0.471
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.471
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.471
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.470
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.470
3nxo	D2B	Dihydrofolate reductase	1.5.1.3	0.469
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.469
4qjc	IXE	Dihydrofolate reductase	1.5.1.3	0.467
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.466
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.465
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.461
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.460
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.460
3ia4	MTX	Dihydrofolate reductase	/	0.459
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.459
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.459
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.458
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.458
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.457
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.455
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.455
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.454
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.453
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.451
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.450
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.450
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.450
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.450
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.450
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.449
3i8a	N22	Dihydrofolate reductase	1.5.1.3	0.449
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.449
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.449
5dc5	B3N	Histone deacetylase 8	3.5.1.98	0.449
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.447
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.447
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.446
3hf6	LX0	Tryptophan 5-hydroxylase 1	1.14.16.4	0.445
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.445
4nr4	2LK	CREB-binding protein	/	0.445
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.444
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.443
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.443
4r20	AER	Cytochrome P450 family 17 polypeptide 2	/	0.443
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.442
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.442
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.441
1fmj	RTL	Retinol dehydratase	/	0.440