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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.21.000
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.553
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.527
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.506
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.494
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.492
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.491
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.488
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.479
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.474
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.472
4nka2K7Fibroblast growth factor receptor 1/0.470
3vs1VSATyrosine-protein kinase HCK2.7.10.20.465
3vryB43Tyrosine-protein kinase HCK2.7.10.20.458
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.455
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.447
2c6eHPMAurora kinase A2.7.11.10.446
4id71G0Activated CDC42 kinase 1/0.444
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.441
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.440
3vs3VSETyrosine-protein kinase HCK2.7.10.20.440