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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/1.000
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.574
1x7hNDPPutative ketoacyl reductase1.3.10.501
3p19NDPPutative blue fluorescent protein/0.497
3sjuNDPKeto reductase/0.497
4hwkNAPSepiapterin reductase1.1.1.1530.491
4j7xNAPSepiapterin reductase1.1.1.1530.490
1ae1NAPTropinone reductase 1/0.487
4j7uNAPSepiapterin reductase1.1.1.1530.485
3qrwNDPPutative ketoacyl reductase1.3.10.483
4dc1NDPPutative ketoacyl reductase1.3.10.483
1w4zNAPPutative ketoacyl reductase1.3.10.480
1xkqNDPUncharacterized protein/0.478
1x7gNAPPutative ketoacyl reductase1.3.10.477
2yutNAPPutative short-chain oxidoreductase/0.476
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.471
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.468
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.468
4qecNAPElxO/0.468
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.467
3l77NJPShort-chain alcohol dehydrogenase/0.467
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.467
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.465
1n5dNDPCarbonyl reductase [NADPH] 1/0.457
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.454
3toxNAPPutative oxidoreductase/0.453
1xg5NAPDehydrogenase/reductase SDR family member 11/0.451
3tn7NJPShort-chain alcohol dehydrogenase/0.450
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.448
1ipeNDPTropinone reductase 21.1.1.2360.448
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.448
2jahNDPClavaldehyde dehydrogenase/0.447
4fn4NADShort chain dehydrogenase/0.444
3f1kNAPUncharacterized oxidoreductase YciK10.443
5idwNAPShort-chain dehydrogenase/reductase SDR/0.441
3gy0NAPNAD(P)-dependent oxidoreductase/0.440