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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.11.000
2pl0STITyrosine-protein kinase Lck2.7.10.20.537
2og81N8Tyrosine-protein kinase Lck2.7.10.20.525
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.511
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.509
2hyySTITyrosine-protein kinase ABL12.7.10.20.485
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.473
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.453
4xbfFADLysine-specific histone demethylase 1A10.452
3lfeZ84Mitogen-activated protein kinase 14/0.450
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.450
1blzACVIsopenicillin N synthase1.21.3.10.449
3vt9YI4Vitamin D3 receptor/0.446
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.445
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.442