sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4bio | 8XQ | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4bio | 8XQ | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 1.000 | |
| 3od4 | 8XQ | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.566 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.503 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 2ohh | FMN | Type A flavoprotein FprA | 1 | 0.451 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 3kuc | GDP | Ras-related protein Rap-1A | / | 0.445 | |
| 2zdy | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.444 | |
| 4jsg | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.440 | |
| 4k81 | GTP | GTPase HRas | / | 0.440 | |
| 4kc2 | WS2 | Histo-blood group ABO system transferase | / | 0.440 | |
| 5c7t | APR | ADP-ribose pyrophosphatase | / | 0.440 |