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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4b76PW1Genome polyprotein3.4.21.98

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4b76PW1Genome polyprotein3.4.21.981.000
4b754VAGenome polyprotein3.4.21.980.602
4b734VAGenome polyprotein3.4.21.980.601
4b71DJLGenome polyprotein3.4.21.980.596
4b741LHGenome polyprotein3.4.21.980.578
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.461
4hyp1A1DNA gyrase subunit B/0.453
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2cduFADNADH oxidase/0.451
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2xrlDXTTetracycline repressor protein class D/0.444
2tctCTCTetracycline repressor protein class D/0.443
1ml3NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.441
3k5uPFQAurora kinase A2.7.11.10.441
3kxw1ZZSaframycin Mx1 synthetase B/0.440
3t7vSAM3-methylornithine synthase/0.440