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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3w32W32Epidermal growth factor receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3w32W32Epidermal growth factor receptor2.7.10.11.000
3poz03PEpidermal growth factor receptor2.7.10.10.658
3w33W19Epidermal growth factor receptor2.7.10.10.610
1xkkFMMEpidermal growth factor receptor2.7.10.10.577
3w2sW2REpidermal growth factor receptor2.7.10.10.534
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.513
4i22IREEpidermal growth factor receptor2.7.10.10.503
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.503
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.500
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.497
5cnnANPEpidermal growth factor receptor2.7.10.10.481
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.478
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.472
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.469
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.467
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.467
3vs3VSETyrosine-protein kinase HCK2.7.10.20.463
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.463
3vt5YI2Vitamin D3 receptor/0.459
4a6cQG9Gag-Pol polyprotein3.4.23.160.459
3w0aDS5Vitamin D3 receptor/0.454
2wotZZGTGF-beta receptor type-12.7.11.300.453
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.453
1yb5NAPQuinone oxidoreductase1.6.5.50.452
2q5g1FAPeroxisome proliferator-activated receptor delta/0.452
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.449
3tqhNDPQuinone oxidoreductase/0.449
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.448
3w2rW2REpidermal growth factor receptor2.7.10.10.448
1mg5NAIAlcohol dehydrogenase1.1.1.10.447
3rj9NADAlcohol dehydrogenase1.1.1.10.446
3ogqAB1Pol polyprotein/0.445
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.443
4a6bQG8Gag-Pol polyprotein3.4.23.160.443
1vikBAYGag-Pol polyprotein/0.442
3vt3VDXVitamin D3 receptor/0.442
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.442
5jlaNADPutative short-chain dehydrogenase/reductase/0.442
3gw9VNILanosterol 14-alpha-demethylase/0.441
4hjoAQ4Epidermal growth factor receptor2.7.10.10.441
1iyzNDPProbable quinone oxidoreductase/0.440
1u3dFADCryptochrome-1/0.440