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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3w0sANPHygromycin-B 4-O-kinase2.7.1.163

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3w0sANPHygromycin-B 4-O-kinase2.7.1.1631.000
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.580
3w0pADPHygromycin-B 4-O-kinase2.7.1.1630.494
4qmlANPSerine/threonine-protein kinase 242.7.11.10.454
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.451
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.448
3w0oADPHygromycin-B 4-O-kinase2.7.1.1630.445
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.444
5ap7SVEDual specificity protein kinase TTK2.7.12.10.444
2qoqANPEphrin type-A receptor 32.7.10.10.442
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.442
4ii5ADPCyclin-dependent kinase 22.7.11.220.441
3i60E86Mitogen-activated protein kinase 12.7.11.240.440
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.440