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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3vvh4BMDual specificity mitogen-activated protein kinase kinase 12.7.12.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3vvh4BMDual specificity mitogen-activated protein kinase kinase 12.7.12.21.000
3orn3ORDual specificity mitogen-activated protein kinase kinase 12.7.12.20.616
3v013V0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.594
1s9jBBMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.592
3dy71CXDual specificity mitogen-activated protein kinase kinase 12.7.12.20.577
2p55MRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.571
3v04V04Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.571
4an35Y0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.570
3os33OSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.561
4an92P7Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.554
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.540
3pp1IZGDual specificity mitogen-activated protein kinase kinase 12.7.12.20.534
4lmnEUIDual specificity mitogen-activated protein kinase kinase 12.7.12.20.533
4anbYQYDual specificity mitogen-activated protein kinase kinase 12.7.12.20.530
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.529
4an2EUIDual specificity mitogen-activated protein kinase kinase 12.7.12.20.486
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.457
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.455
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3sls77DDual specificity mitogen-activated protein kinase kinase 12.7.12.20.453
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.453
1k6pXN3Gag-Pol polyprotein3.4.23.160.451
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.451
1k6cMK1Gag-Pol polyprotein3.4.23.160.450
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.449
1knuYPAPeroxisome proliferator-activated receptor gamma/0.446
3opdHIEHeat shock protein 83/0.446
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.445
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.445
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.444
3wfjNAD2-dehydropantoate 2-reductase/0.444
4hee14RPeroxisome proliferator-activated receptor gamma/0.444
1k6tXN1Gag-Pol polyprotein3.4.23.160.443
4nka2K7Fibroblast growth factor receptor 1/0.443
1y0s331Peroxisome proliferator-activated receptor delta/0.441
5br4NADLactaldehyde reductase1.1.1.770.441
1difA85Gag-Pol polyprotein/0.440
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.440
5hwsNAP2-dehydropantoate 2-reductase/0.440