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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3vs2VSBTyrosine-protein kinase HCK2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3vs2VSBTyrosine-protein kinase HCK2.7.10.21.000
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.537
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.531
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.529
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.528
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.520
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.518
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.512
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.504
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.503
3vs1VSATyrosine-protein kinase HCK2.7.10.20.494
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.494
3vs3VSETyrosine-protein kinase HCK2.7.10.20.493
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.491
3poz03PEpidermal growth factor receptor2.7.10.10.491
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.485
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.483
3vryB43Tyrosine-protein kinase HCK2.7.10.20.482
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.473
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.466
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.463
4i22IREEpidermal growth factor receptor2.7.10.10.452
1bygSTUTyrosine-protein kinase CSK/0.451
2c6eHPMAurora kinase A2.7.11.10.451
3w33W19Epidermal growth factor receptor2.7.10.10.447
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
3w32W32Epidermal growth factor receptor2.7.10.10.446
4id71G0Activated CDC42 kinase 1/0.441
3w2sW2REpidermal growth factor receptor2.7.10.10.440
4gk2L66Ephrin type-A receptor 32.7.10.10.440