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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3uwlFOZThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3uwlFOZThymidylate synthase/1.000
4o7uTHFThymidylate synthase/0.590
3bgxMEFThymidylate synthase/0.571
2ftoCB3Thymidylate synthase/0.556
1tysDHFThymidylate synthase/0.547
3bhrTHGThymidylate synthase/0.539
1tduCB3Thymidylate synthase/0.525
4gevCB3Thymidylate synthase/0.518
1fwmCB3Thymidylate synthase/0.494
4ez8DHFThymidylate synthase2.1.1.450.494
4knzCB3Thymidylate synthase/0.493
1trgCB3Thymidylate synthase/0.492
3bhlTHGThymidylate synthase/0.489
1an5CB3Thymidylate synthase/0.487
1f4fTP3Thymidylate synthase/0.487
2aazCB3Thymidylate synthase2.1.1.450.486
2bbqPFGThymidylate synthase/0.477
1jtuLYBThymidylate synthase/0.476
4fogC2FThymidylate synthase ThyA/0.476
1kzjCB3Thymidylate synthase/0.473
1kceCB3Thymidylate synthase/0.467
4fqsLYAThymidylate synthase ThyA/0.464
4j6bPLOCytochrome P450 monooxygenase/0.463
1hvyD16Thymidylate synthase2.1.1.450.452
4jbtASDCytochrome P450 monooxygenase/0.449
1jujLYAThymidylate synthase2.1.1.450.448
1dduCB3Thymidylate synthase/0.447
4q71FADBifunctional protein PutA/0.446
3kpkFADSulfide-quinone reductase/0.445
4isk1JYThymidylate synthase/0.445
1ju6LYAThymidylate synthase2.1.1.450.444
1dnaCB3Thymidylate synthase/0.443
1jtqLY3Thymidylate synthase/0.440