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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3uj7SAMPhosphoethanolamine N-methyltransferase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3uj7SAMPhosphoethanolamine N-methyltransferase/1.000
4r6xSAHPhosphoethanolamine N-methyltransferase/0.664
3uj8SFGPhosphoethanolamine N-methyltransferase/0.637
4fgzSAHPhosphoethanolamine N-methyltransferase/0.613
4iv0SAMPhosphoethanolamine N-methyltransferase, putative/0.582
4mwzSAMPhosphoethanolamine N-methyltransferase, putative/0.561
4iv8SAMPhosphoethanolamine N-methyltransferase,putative/0.532
5epeSAHUncharacterized protein/0.502
5e8jSAHmRNA cap guanine-N7 methyltransferase2.1.1.560.497
5icfSAH(S)-norcoclaurine 6-O-methyltransferase/0.491
5je3SAHMethyl transferase/0.486
4krhSAMPhosphoethanolamine N-methyltransferase 2/0.478
5bp7SAHSAM-dependent methyltransferase/0.477
3p9kSAHCaffeic acid O-methyltransferase/0.471
2z1mNDPGDP-mannose 4,6-dehydratase/0.469
1qanSAHrRNA adenine N-6-methyltransferase2.1.1.1840.459
3ha3SAHHydroxymycolate synthase MmaA42.1.10.459
3tljSAHUncharacterized protein/0.452
1qaoSAMrRNA adenine N-6-methyltransferase2.1.1.1840.451
3bgvSAHmRNA cap guanine-N7 methyltransferase2.1.1.560.450
3ha5SFGHydroxymycolate synthase MmaA42.1.10.450
1qaqSFGrRNA adenine N-6-methyltransferase2.1.1.1840.448
2eg5SAH7-methylxanthosine synthase 1/0.448
3grrSAHProbable ribosomal RNA small subunit methyltransferase A/0.448
1ve3SAMUncharacterized protein/0.443
3reoSAH(Iso)eugenol O-methyltransferase2.1.1.1460.443
3i53SAH2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase/0.442
5bw4SAMUncharacterized protein/0.442
1t2dNADL-lactate dehydrogenase1.1.1.270.441
3kpjSAHPhenylethanolamine N-methyltransferase2.1.1.280.441