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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3tscNADUncharacterized protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3tscNADUncharacterized protein/1.000
3sx2NADUncharacterized protein/0.536
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.521
4fn4NADShort chain dehydrogenase/0.504
4yaiNAIC alpha-dehydrogenase/0.504
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.502
3s55NADPutative short-chain dehydrogenase/reductase/0.498
4qecNAPElxO/0.494
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.494
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.493
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.491
4yagNAIC alpha-dehydrogenase/0.489
2dteNAIGlucose 1-dehydrogenase related protein/0.488
1ipeNDPTropinone reductase 21.1.1.2360.487
1ae1NAPTropinone reductase 1/0.483
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.483
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.482
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.481
4gh5NADShort-chain dehydrogenase/reductase SDR/0.480
4nbwNADShort-chain dehydrogenase/reductase SDR/0.480
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.477
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.477
5jlaNADPutative short-chain dehydrogenase/reductase/0.477
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.476
5jy1NADPutative short-chain dehydrogenase/reductase/0.473
1iy8NADLevodione reductase/0.470
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.470
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.469
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.468
3ak4NADNADH-dependent quinuclidinone reductase/0.466
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.462
4hwkNAPSepiapterin reductase1.1.1.1530.462
4j7uNAPSepiapterin reductase1.1.1.1530.462
2wdzNADGalactitol dehydrogenase/0.461
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.458
3qrwNDPPutative ketoacyl reductase1.3.10.458
4j7xNAPSepiapterin reductase1.1.1.1530.457
1xg5NAPDehydrogenase/reductase SDR family member 11/0.456
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.456
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
3wdsNADNADH-dependent quinuclidinone reductase/0.454
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.453
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.452
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.450
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.450
3p19NDPPutative blue fluorescent protein/0.449
1pr9NAPL-xylulose reductase1.1.1.100.448
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.446
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.446
3lqfNADGalactitol dehydrogenase/0.446
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.446
3sjuNDPKeto reductase/0.445
3d3wNAPL-xylulose reductase1.1.1.100.442
1wntNAPL-xylulose reductase1.1.1.100.441
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
4dc1NDPPutative ketoacyl reductase1.3.10.441
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.441
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.441
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.440